SCHEMBL6723899

SCHEMBL6723899

COc1ccc([C@H]2CC(=O)c3cc(OC)cc(OC)c3O2)cc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.62
CYP19A1 P11511 6/20 0.62
CYP3A4 P08684 2/20 0.62
NPC1 O15118 1/20 0.59
MAPT P10636 1/20 0.59
RAB9A P51151 1/20 0.59
MAP2K3 P46734 1/20 0.59
ABCG2 Q9UNQ0 2/20 0.57
ABCB1 P08183 1/20 0.57
AR P10275 1/20 0.57
KDM4E B2RXH2 1/20 0.57
ALDH1A1 P00352 1/20 0.57
HPGD P15428 1/20 0.57
MAPK1 P28482 1/20 0.57
HSD17B10 Q99714 1/20 0.57
ACHE P22303 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2879029 0.92 ABCG2 (0.67) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL5085606 0.91 CYP19A1 (0.63) MAOBCYP19A1CYP3A4MAPTABCG2
SCHEMBL16894664 0.85 MAOB (0.60) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL3368230 0.81 CYP19A1 (0.59) CYP19A1CYP3A4NPC1MAPTRAB9A
SCHEMBL773767 0.81 CYP19A1 (0.66) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL6700335 0.80 ABCG2 (0.65) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL22680315 0.80 ABCB1 (0.87) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL17318042 0.80 CYP1A1 (0.67) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL7200859 0.80 CYP1A1 (0.67) MAOBCYP19A1CYP3A4NPC1MAPT
SCHEMBL18106040 0.79 ALDH1A1 (0.83) MAOBCYP19A1CYP3A4NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6677350-B1 ADMINISTERING CHALCONE-LIKE VINYLCARBONYL COMPOUNDS TO PREVENT OR TREAT MYCOBACTERIUM INFECTIONS/TUBERCULOSIS ADVANCED LIFE SCIENCES, INC. 2004-01-13 US disclosed