Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.49 |
| ▸ | MMP9 | P14780 | 8/20 | 0.49 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | MMP3 | P08254 | 7/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723870 | 0.89 | MMP2 (0.41) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6722440 | 0.86 | MMP2 (0.40) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6724321 | 0.75 | MMP2 (0.49) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6722526 | 0.74 | MMP13 (0.41) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6719868 | 0.74 | MMP2 (0.45) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6722448 | 0.73 | MMP2 (0.64) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6719280 | 0.73 | MMP2 (0.39) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6727012 | 0.73 | DUT (0.50) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6719811 | 0.73 | MMP2 (0.54) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6081543 | 0.72 | MMP2 (0.86) | MMP2MMP9MMP13MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |