Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 6/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722486 | 0.88 | DUT (0.46) | DUTMMP2MMP9PTGESNR3C1 | |
| SCHEMBL6723939 | 0.87 | DUT (0.45) | DUTMMP2MMP9PTGESNR3C1 | |
| SCHEMBL6722415 | 0.84 | DUT (0.44) | DUTMMP2MMP9PTGESNR3C1 | |
| SCHEMBL6722440 | 0.82 | MMP2 (0.40) | DUTMMP2MMP9MMP13LMNA | |
| SCHEMBL6722449 | 0.79 | DUT (0.41) | DUTMMP2MMP9PTGESMMP13 | |
| SCHEMBL6726942 | 0.77 | DUT (0.44) | DUTMMP2MMP9PTGESNR3C1 | |
| SCHEMBL6724062 | 0.77 | DUT (0.40) | DUTMMP2MMP9MMP13MMP1 | |
| SCHEMBL6724487 | 0.73 | MMP2 (0.49) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL6719609 | 0.71 | DUT (0.56) | DUTMMP2MMP9PTGESNR3C1 | |
| SCHEMBL6722526 | 0.71 | MMP13 (0.41) | MMP2MMP9MMP13LMNAMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |