Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.55 |
| ▸ | HTR1F | P30939 | 16/20 | 0.55 |
| ▸ | HTR1D | P28221 | 12/20 | 0.55 |
| ▸ | HTR1B | P28222 | 11/20 | 0.55 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726471 | 0.95 | HTR1A (0.52) | HTR1AHTR1FHTR1DHTR1BGRM5 | |
| SCHEMBL6726534 | 0.85 | HTR1F (0.49) | HTR1AHTR1FHTR1DHTR1B | |
| SCHEMBL6724792 | 0.84 | HTR1A (0.49) | HTR1AHTR1FHTR1DHTR1BGRM5 | |
| SCHEMBL6726991 | 0.84 | HTR1A (0.48) | HTR1AHTR1FHTR1DHTR1BHTR2A | |
| SCHEMBL6671344 | 0.83 | NPC1 (0.54) | HTR1AHTR1FHTR1DHTR1BGRM5 | |
| SCHEMBL6722238 | 0.82 | HTR1A (0.47) | HTR1AHTR1FHTR1DHTR1BGRM5 | |
| SCHEMBL6722139 | 0.81 | RXFP1 (0.54) | HTR1AHTR1FHTR1DHTR1BGRM5 | |
| SCHEMBL6722245 | 0.81 | HTR1F (0.51) | HTR1AHTR1FHTR1DHTR1BHTR2A | |
| SCHEMBL6724701 | 0.80 | MET (0.48) | HTR1AHTR1FHTR1DHTR1BPIM1 | |
| SCHEMBL6734018 | 0.80 | MET (0.51) | HTR1AHTR1FHTR1DHTR1BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |