Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | TPMT | P51580 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037857 | 0.76 | HSD11B1 (0.42) | P2RX7TPMT | |
| Adamantane SCHEMBL6725055 | 0.74 | TPMT (0.49) | MEN1KMT2ATPMTLMNAALDH1A1 | |
| SCHEMBL28363484 | 0.72 | P2RX7 (0.58) | MEN1KMT2AP2RX7LMNA | |
| SCHEMBL25527372 | 0.71 | TPMT (0.49) | MEN1KMT2ATPMTLMNAALDH1A1 | |
| SCHEMBL17854065 | 0.69 | TPMT (0.58) | TPMTLMNAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL14244393 | 0.69 | KDM4E (0.64) | MEN1KMT2AP2RX7LMNAALDH1A1 | |
| SCHEMBL25657997 | 0.68 | P2RX7 (0.47) | MEN1KMT2AP2RX7LMNAALDH1A1 | |
| SCHEMBL98155 | 0.68 | P2RX7 (0.44) | MEN1KMT2AP2RX7LMNAALDH1A1 | |
| SCHEMBL15536305 | 0.67 | SCN9A (0.66) | P2RX7 | |
| SCHEMBL19895701 | 0.67 | ALDH1A1 (0.53) | KMT2AP2RX7LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |