Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6720857 | 0.92 | KMT2A (0.58) | LMNAPPARGTSHRHDAC1HDAC6 | |
| SCHEMBL6724972 | 0.89 | PPARG (0.46) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL1004019 | 0.84 | HDAC1 (0.71) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL25138742 | 0.84 | HDAC1 (0.71) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL6725022 | 0.83 | KMT2A (0.69) | TSHRHDAC1HDAC6ALDH1A1HPGD | |
| SCHEMBL3455861 | 0.77 | HDAC1 (0.67) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL3178210 | 0.76 | HDAC1 (0.65) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL968384 | 0.76 | LMNA (0.72) | LMNAPPARGTSHRMAPK1HDAC1 | |
| SCHEMBL1195514 | 0.75 | LMNA (0.78) | LMNATSHRMAPK1HDAC1HDAC6 | |
| SCHEMBL29953564 | 0.75 | HDAC1 (0.59) | LMNAPPARGTSHRMAPK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |