Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332583 | 0.91 | LMNA (0.42) | LMNAPKMNPSR1SSTR5ALDH1A1 | |
| SCHEMBL11257227 | 0.88 | LMNA (0.47) | LMNAPKMNPSR1SSTR5ALDH1A1 | |
| SCHEMBL6171975 | 0.86 | PARP1 (0.58) | LMNAPKMNPSR1SSTR5ALDH1A1 | |
| SCHEMBL783714 | 0.84 | LMNA (0.59) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL673400 | 0.84 | LMNA (0.44) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL9749197 | 0.77 | SSTR5 (0.37) | LMNASSTR5HPGD | |
| SCHEMBL2548565 | 0.75 | LMNA (0.44) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL15625037 | 0.75 | PKM (0.39) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL11223734 | 0.75 | IDO1 (0.39) | LMNAPKMNPSR1SSTR5ALDH1A1 | |
| SCHEMBL14907126 | 0.74 | CCR5 (0.38) | SSTR5MAPTTSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784620-A1 | N-SUBSTITUTED PIPERIDINYL BICYCLIC BENZOATE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-23 | — | — | EP | claimed |
| WO-1996010027-A1 | N-SUBSTITUTED PIPERIDINYL BICYCLIC BENZOATE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-04-04 | — | — | WO | claimed |
| CN-107660148-A | Compounds for preventing or treating organ damage | 萨尔法泰克有限公司 | 2018-02-02 | — | — | CN | disclosed |
| EP-2605658-B1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME (US) | 2016-03-23 | — | — | EP | disclosed |
| EP-2935232-A1 | COMPOUNDS FOR PROTECTION OF CELLS | Sulfateq B.V. (NL) | 2015-10-28 | — | — | EP | disclosed |
| EP-2582674-B1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | CYMABAY THERAPEUTICS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2014098586-A1 | COMPOUNDS FOR PROTECTION OF CELLS | SULFATEQ B.V. (NL) | 2014-06-26 | — | — | WO | disclosed |
| US-8742110-B2 | Spiroxazolidinone compounds | MERCK SHARP & DOHME CORP. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8476308-B2 | GPR120 receptor agonists and uses thereof | METABOLEX, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-8476308-B2 | GPR120 receptor agonists and uses thereof | METABOLEX, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| EP-0307172-B1 | Improvements in or relating to specific 5-HT3 antagonists | LILLY CO ELI (US) | 1995-10-11 | — | — | EP | disclosed |
| US-5442078-A | Intermediates for specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0625149-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| US-5364863-A | Treatment of migraine, emesis, schizophrenia, anxiety, gastrointestinal disorders | ELI LILLY AND COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| WO-1993016072-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-19 | — | — | WO | disclosed |
| US-4997956-A | Analgesics | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4921982-A | 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0307172-A2 | Improvements in or relating to specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4329459-A | ENDOPEROXIDE CYCLOXGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1982-05-11 | — | — | US | disclosed |