Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL17375316 | 0.85 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL5875233 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL5875221 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL238240 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL31272367 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL5874391 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL3454436 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL2767900 | 0.83 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL7039332 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL7039340 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680286-B1 | CONTAINING AN ORGANIC POLYELECTROLYTE BUILDER, QUATERNARY AMMONIUM ACRYLIC POLYMERS, WHICH ARE ESPECIALLY USEFUL FOR WASHING CLOTHES | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2004-01-20 | — | — | US | disclosed |