SCHEMBL672741

SCHEMBL672741

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 4/20 0.36
KLKB1 P03952 3/20 0.36
CARM1 Q86X55 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
MALT1 Q9UDY8 1/20 0.35
TRPV1 Q8NER1 2/20 0.34
F10 P00742 1/20 0.34
DHODH Q02127 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10140160 0.94 CARM1 (0.37) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL15693449 0.94 PDE4B (0.35) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL14360665 0.93 KDM4E (0.37) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL782369 0.93 PDE4B (0.37) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL14470584 0.93 PDE4B (0.36) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL11959530 0.92 KLKB1 (0.35) PDE4BKLKB1CARM1TRPV1
SCHEMBL782481 0.92 DHODH (0.36) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL2935274 0.92 CARM1 (0.36) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL4491830 0.92 PDE4B (0.35) PDE4BKLKB1CARM1KDM4EMEN1
SCHEMBL4478603 0.91 PDE4B (0.38) PDE4BKLKB1CARM1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 255 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2910125-B1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2018-05-02 EP claimed
US-20160270396-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2016-09-22 US claimed
US-9408390-B2 Insecticide compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-09 US claimed
US-20150282484-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2015-10-08 US claimed
EP-2910125-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2015-08-26 EP claimed
EP-2474227-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-15 EP claimed
EP-2484209-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-01 EP claimed
EP-2484209-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2012-08-08 EP claimed
EP-2474227-A1 Insecticide compositions Sumitomo Chemical Co., Ltd (JP) 2012-07-11 EP claimed
EP-1719409-B1 INSECTICIDE COMPOSITION SUMITOMO CHEMICAL CO (JP) 2012-07-11 EP claimed
US-20100227893-A1 INSECTICIDE COMPOSITIONS OHKAWARA YUICHI 2010-09-09 US claimed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
US-20070259787-A1 Insecticide Compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-08 US claimed
EP-1719409-A1 INSECTICIDE COMPOSITION Sumitomo Chemical Takeda Agro Company, Limited (JP) 2006-11-08 EP claimed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides FMC CORPORATION 2004-10-07 US disclosed
EP-1416797-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 EP disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 PDE4B 1470/4885KLKB1 2862/4885CARM1 1166/4885
US-20100227893-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 PDE4B 137/4885KLKB1 4721/4885CARM1 402/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 PDE4B 2427/4885KLKB1 3379/4885CARM1 3483/4885
US-20070259787-A1 Insecticide Compositions DDT, NISCH, ITPR3 PDE4B 137/4885KLKB1 4721/4885CARM1 402/4885
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides CYP4B1, CYP1B1, CYP2E1 PDE4B 908/4885KLKB1 4254/4885CARM1 1207/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 PDE4B 262/4885KLKB1 3263/4885CARM1 2370/4885
US-20160270396-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 PDE4B 137/4885KLKB1 4721/4885CARM1 402/4885
US-20150282484-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 PDE4B 137/4885KLKB1 4721/4885CARM1 402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.