SCHEMBL4491830

SCHEMBL4491830

Cc1cc(I)cc(C(=O)NC(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 4/20 0.35
DHODH Q02127 2/20 0.35
CARM1 Q86X55 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
KLKB1 P03952 3/20 0.34
TRPV1 Q8NER1 2/20 0.34
OPRL1 P41146 1/20 0.33
F9 P00740 1/20 0.33
F10 P00742 1/20 0.33
STIM1 Q13586 1/20 0.33
ORAI1 Q96D31 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16622523 0.94 PDE4B (0.35) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL672741 0.92 PDE4B (0.36) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL14360665 0.92 KDM4E (0.37) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL14470584 0.91 PDE4B (0.36) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL958266 0.91 CARM1 (0.38) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL2935274 0.90 CARM1 (0.36) PDE4BCARM1KDM4EMEN1ALDH1A1
SCHEMBL782481 0.90 DHODH (0.36) PDE4BDHODHCARM1KDM4EMEN1
SCHEMBL4478603 0.90 PDE4B (0.38) PDE4BCARM1KDM4EMEN1ALDH1A1
SCHEMBL4675046 0.90 CARM1 (0.37) PDE4BCARM1KLKB1F9F10
SCHEMBL29393434 0.89 DHODH (0.39) PDE4BDHODHCARM1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-8735431-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-05-27 US disclosed
US-8299036-B2 Active agent combinations with insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2012-10-30 US disclosed
US-8299036-B2 Active agent combinations with insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2012-10-30 US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-7199138-B2 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-04-03 US disclosed
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP PDE4B 66/4885DHODH 2787/4885CARM1 1638/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS PDE4B 401/4885DHODH 2032/4885CARM1 3191/4885
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties AADAC, ANTXR2, ACHE PDE4B 199/4885DHODH 2657/4885CARM1 2430/4885
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 PDE4B 811/4885DHODH 2465/4885CARM1 1314/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 PDE4B 277/4885DHODH 3666/4885CARM1 781/4885
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 PDE4B 828/4885DHODH 2433/4885CARM1 1357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.