Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448287 | 0.91 | HTT (0.48) | MAPTPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL6734102 | 0.85 | PRKAG1 (0.46) | MAPTPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL6722059 | 0.84 | ALDH1A1 (0.43) | MAPTHTTMTNR1AMTNR1BKDM4E | |
| SCHEMBL6667683 | 0.84 | MTNR1A (0.53) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL30267364 | 0.84 | MTNR1A (0.53) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL6724529 | 0.83 | PIM1 (0.41) | MAPTHTTMTNR1AMTNR1BKDM4E | |
| SCHEMBL6722084 | 0.83 | PIM1 (0.48) | MAPTHTTMTNR1AMTNR1BKDM4E | |
| SCHEMBL6726958 | 0.82 | KDM4E (0.39) | MAPTPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL6729681 | 0.82 | PIM1 (0.43) | MAPTHTTMTNR1AMTNR1BKDM4E | |
| SCHEMBL6389885 | 0.80 | GABRA1 (0.54) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |