Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10906759 | 0.89 | POLB (0.51) | LMNAHSD17B10POLBALDH1A1 | |
| SCHEMBL10906153 | 0.87 | ASAH1 (0.47) | LMNAHSD17B10POLBALDH1A1CES2 | |
| SCHEMBL19228532 | 0.86 | CYP2C19 (0.53) | CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL643461 | 0.86 | CYP2C19 (0.53) | CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10906658 | 0.85 | NAAA (0.49) | POLBALDH1A1CES2CES1 | |
| SCHEMBL10906646 | 0.85 | NAAA (0.49) | POLBALDH1A1CES2CES1 | |
| SCHEMBL10790040 | 0.85 | NAAA (0.49) | POLBALDH1A1CES2CES1 | |
| SCHEMBL10905511 | 0.85 | NAAA (0.49) | POLBALDH1A1CES2CES1 | |
| SCHEMBL10907429 | 0.85 | NAAA (0.49) | POLBALDH1A1CES2CES1 | |
| SCHEMBL13385031 | 0.84 | CYP2C19 (0.49) | CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | claimed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | claimed |
| US-11045402-B2 | Hair cosmetic composition | KAO CORPORATION (JP) | 2021-06-29 | — | — | US | disclosed |
| US-10959925-B2 | Hair cosmetic composition | KAO CORPORATION (JP) | 2021-03-30 | — | — | US | disclosed |
| CN-106999379-B | Hair deforming agent | 花王株式会社 | 2020-05-05 | — | — | CN | disclosed |
| EP-3228303-B1 | AGENT FOR HAIR DEFORMING TREATMENT | KAO CORP (JP) | 2020-03-18 | — | — | EP | disclosed |
| US-20190290564-A1 | HAIR COSMETIC COMPOSITION | KAO CORPORATION (JP) | 2019-09-26 | — | — | US | disclosed |
| US-20190254943-A1 | HAIR COSMETIC COMPOSITION | KAO CORPORATION (JP) | 2019-08-22 | — | — | US | disclosed |
| US-20190224093-A1 | HAIR COSMETIC COMPOSITION | KAO CORPORATION (JP) | 2019-07-25 | — | — | US | disclosed |
| US-20190125052-A1 | METHOD FOR TREATING HAIR | KAO CORPORATION (JP) | 2019-05-02 | — | — | US | disclosed |
| EP-3463264-A1 | METHOD FOR TREATING HAIR | Kao Corporation (JP) | 2019-04-10 | — | — | EP | disclosed |
| EP-1187819-B1 | N-SUBSTITUTED PERHYDRO DIAZINE | BASF AG (DE) | 2003-07-23 | — | — | EP | disclosed |
| EP-0835248-B1 | 1-AMINO-3-BENZYLURACILS | BASF AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| US-6150303-A | Substituted 3-phenylisoxazolines | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-21 | — | — | US | disclosed |
| CN-1189824-A | 1-amino-3-benzyluracils | BASF AG (DE) | 1998-08-05 | — | — | CN | disclosed |
| EP-0835248-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997001543-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-01-16 | — | — | WO | disclosed |
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | disclosed |
| US-4619794-A | Spontaneous preparation of small unilamellar liposomes | CIBA-GEIGY CORPORATION (US) | 1986-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11045402-B2 | Hair cosmetic composition | CUTA, GRHPR, POLR1C | CYP2C19 1445/4885CYP1A2 1333/4885CYP3A4 1895/4885 |
| US-10959925-B2 | Hair cosmetic composition | CUTA, POLR1C, GRHPR | CYP2C19 862/4885CYP1A2 710/4885CYP3A4 1786/4885 |
| US-20190254943-A1 | HAIR COSMETIC COMPOSITION | CUTA, POLR1C, GRHPR | CYP2C19 862/4885CYP1A2 710/4885CYP3A4 1786/4885 |
| US-20190125052-A1 | METHOD FOR TREATING HAIR | GRHPR, TYR, POLR1C | CYP2C19 757/4885CYP1A2 352/4885CYP3A4 848/4885 |
| US-20190224093-A1 | HAIR COSMETIC COMPOSITION | CUTA, GRHPR, POLR1C | CYP2C19 1445/4885CYP1A2 1333/4885CYP3A4 1895/4885 |
| US-20190290564-A1 | HAIR COSMETIC COMPOSITION | GRHPR, POLR1C, TYR | CYP2C19 1070/4885CYP1A2 818/4885CYP3A4 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.