Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6729315 | 1.00 | OPRM1 (0.52) | OPRM1OPRK1OPRD1TACR1PSEN1 | |
| SCHEMBL21359781 | 0.89 | PSEN1 (0.53) | OPRM1OPRK1OPRD1TACR1PSEN1 | |
| SCHEMBL20995912 | 0.85 | PSEN1 (0.53) | OPRM1TACR1PSEN1PSEN2APH1B | |
| SCHEMBL2624933 | 0.85 | OPRM1 (0.55) | OPRM1OPRK1OPRD1PSEN1PSEN2 | |
| SCHEMBL2624934 | 0.85 | OPRM1 (0.55) | OPRM1OPRK1OPRD1PSEN1PSEN2 | |
| SCHEMBL13303676 | 0.81 | OPRM1 (0.51) | OPRM1OPRK1OPRD1KDM4EALDH1A1 | |
| SCHEMBL411284 | 0.81 | OPRM1 (0.55) | OPRM1OPRK1OPRD1PSEN1PSEN2 | |
| SCHEMBL411240 | 0.81 | OPRM1 (0.51) | OPRM1OPRK1OPRD1KDM4EALDH1A1 | |
| SCHEMBL410116 | 0.81 | OPRM1 (0.51) | OPRM1OPRK1OPRD1KDM4EALDH1A1 | |
| SCHEMBL410620 | 0.81 | OPRM1 (0.51) | OPRM1OPRK1OPRD1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040049049-A1 | Stereoselective synthesis of 1,2-disubstituted cycloalkyls | JOHNSON MATTHEY PHARMACEUTICAL MATERIALS, INC. | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040049049-A1 | Stereoselective synthesis of 1,2-disubstituted cycloalkyls | CYP8B1, AGTR1, AGTR2 | OPRM1 923/4885OPRK1 660/4885OPRD1 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.