Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6729649 | 0.86 | HTR2C (0.47) | HTR2CSMN1; SMN2 | |
| SCHEMBL6733358 | 0.78 | PRKAB2 (0.37) | CYP1A2CYP2C19DHODHTET2TET1 | |
| SCHEMBL6734102 | 0.77 | PRKAG1 (0.46) | CYP1A2CYP2C19MTNR1AMTNR1B | |
| SCHEMBL6729681 | 0.77 | PIM1 (0.43) | CYP1A2CYP2C19SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL6724529 | 0.76 | PIM1 (0.41) | CYP1A2CYP2C19SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL6728722 | 0.76 | MAPT (0.44) | CYP1A2CYP2C19SMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL6722084 | 0.75 | PIM1 (0.48) | CYP1A2CYP2C19SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL6726958 | 0.74 | KDM4E (0.39) | CYP1A2CYP2C19DHODHMTNR1AMTNR1B | |
| SCHEMBL6722059 | 0.74 | ALDH1A1 (0.43) | CYP1A2CYP2C19SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL6726280 | 0.74 | DHODH (0.46) | CYP1A2SMN1; SMN2DHODHHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |