Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MIF | P14174 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076060 | 0.75 | PARP10 (0.75) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL29752161 | 0.75 | PARP10 (0.75) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL1894080 | 0.73 | PARP10 (0.78) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL29369705 | 0.69 | PARP10 (1.00) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL67710 | 0.69 | PARP10 (1.00) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL18607288 | 0.68 | MAOA (0.91) | PARP11PARP1PARP10PDPK1CYP2A6 | |
| SCHEMBL18716863 | 0.68 | MAOA (0.91) | PARP11PARP1PARP10PDPK1CYP2A6 | |
| SCHEMBL4874556 | 0.68 | MAOA (0.91) | PARP11PARP1PARP10PDPK1CYP2A6 | |
| SCHEMBL29766301 | 0.68 | MAOA (0.91) | PARP11PARP1PARP10PDPK1CYP2A6 | |
| SCHEMBL4573854 | 0.68 | MAOA (0.91) | PARP11PARP1PARP10PDPK1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040019018-A1 | Tetrahydro-2H-2-aza-cyclopenta(a)inden-one or derivatives, useful for treating cancers including prostate cancer, inflammatory, autoimmune and neurological disorders including Alzheimer's disease | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-01-29 | — | — | US | disclosed |
| WO-2001083449-A2 | RIGID PYRROLIDONE MODULATORS OF PKC | GEORGETOWN UNIVERSITY (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019018-A1 | Tetrahydro-2H-2-aza-cyclopenta(a)inden-one or derivatives, useful for treating cancers including prostate cancer, inflammatory, autoimmune and neurological disorders including Alzheimer's disease | PRKAR2A, PRKAR2B, PRKG1 | PARP11 789/4885PARP1 1116/4885PARP10 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.