Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157315 | 0.81 | L3MBTL1 (0.54) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2908596 | 0.80 | ALDH1A1 (0.69) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16467862 | 0.79 | KDM4E (0.43) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL23873637 | 0.78 | ALDH1A1 (0.72) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13762188 | 0.77 | ALDH1A1 (0.69) | ALDH1A1LTA4HCYP3A4CYP2C19MAPT | |
| SCHEMBL6833672 | 0.76 | LTA4H (0.73) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6730610 | 0.75 | LTA4H (0.72) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL171745 | 0.75 | ALDH1A1 (1.00) | ALDH1A1LTA4HMAPTMEN1PABPC1 | |
| SCHEMBL10556321 | 0.75 | LTA4H (0.57) | ALDH1A1LTA4HCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5605047 | 0.75 | LTA4H (0.82) | ALDH1A1LTA4HCYP2C19MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | disclosed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | ALDH1A1 1187/4885LTA4H 1721/4885CYP3A4 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.