Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11140420 | 0.76 | CREBBP (0.39) | PARP1ALDH1A1L3MBTL1 | |
| SCHEMBL783714 | 0.75 | LMNA (0.59) | PKMLMNANPSR1TSHRALDH1A1 | |
| SCHEMBL4829723 | 0.75 | PARP1 (0.74) | PARP1 | |
| SCHEMBL672668 | 0.73 | LMNA (0.44) | PARP1PKMLMNANPSR1TSHR | |
| SCHEMBL2548565 | 0.73 | LMNA (0.44) | PARP1PKMLMNANPSR1TSHR | |
| SCHEMBL15625037 | 0.73 | PKM (0.39) | PARP1PKMLMNANPSR1TSHR | |
| SCHEMBL15129966 | 0.71 | PARP1 (0.37) | PARP1PKMLMNANPSR1TSHR | |
| SCHEMBL23642797 | 0.71 | PARP1 (0.44) | PARP1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL21113820 | 0.71 | PARP1 (0.44) | PARP1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL21113893 | 0.71 | PARP1 (0.44) | PARP1LMNAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |