Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6735648 | 1.00 | ALDH1A1 (0.42) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL4421840 | 0.89 | ALDH1A1 (0.50) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL6482103 | 0.89 | ALDH1A1 (0.50) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL6481421 | 0.87 | THRB (0.46) | ALDH1A1THRBLMNASMN1; SMN2MAPK1 | |
| SCHEMBL6735652 | 0.82 | ALDH1A1 (0.46) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL4435139 | 0.81 | MBTPS1 (0.47) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL4435142 | 0.81 | MBTPS1 (0.47) | ALDH1A1THRBLMNACASP1CASP3 | |
| SCHEMBL6475048 | 0.80 | ALDH1A1 (0.47) | ALDH1A1THRBLMNASMN1; SMN2 | |
| SCHEMBL4433880 | 0.80 | ALDH1A1 (0.47) | ALDH1A1THRBLMNASMN1; SMN2 | |
| SCHEMBL4425138 | 0.80 | ALDH1A1 (0.53) | ALDH1A1THRBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040019061-A1 | 1-H-3-arylpirrolidine-2,4-dione derivatives | FISCHER REINER (DE) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019061-A1 | 1-H-3-arylpirrolidine-2,4-dione derivatives | PRXL2A, DDT, CYP4B1 | ALDH1A1 792/4885THRB 1717/4885LMNA 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.