Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL28623908 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL218867 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL1937600 | 0.80 | LMNA (0.54) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| Hydrochloric Acid SCHEMBL7036575 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL2118284 | 0.80 | ATM (0.55) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL23529356 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL23561312 | 0.76 | LMNA (0.48) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL6261682 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL3268354 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL28774615 | 0.76 | LMNA (0.48) | SMN1; SMN2LMNAHTTRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109280044-B | Raltitrexed impurity C and preparation and application thereof | 南京正大天晴制药有限公司 | 2021-04-02 | — | — | CN | claimed |
| US-20260125356-A1 | TREATMENT OF LEISHMANIASIS | THE UNIV OF DURHAM (GB) | 2026-05-07 | — | — | US | disclosed |
| EP-4605086-A1 | TREATMENT OF LEISHMANIASIS | The University of Durham (GB) | 2025-08-27 | — | — | EP | disclosed |
| CN-114667282-B | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20240150356-A1 | Pyrimidine amide compounds and use thereof | ALPHALA CO., LTD. (TW) | 2024-05-09 | — | — | US | disclosed |
| WO-2024084186-A1 | TREATMENT OF LEISHMANIASIS | THE UNIVERSITY OF DURHAM (GB) | 2024-04-25 | — | — | WO | disclosed |
| WO-2023244430-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO., LTD. (TW) | 2023-12-21 | — | — | WO | disclosed |
| EP-4048656-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | Alphala Co., Ltd. (TW) | 2022-08-31 | — | — | EP | disclosed |
| CN-114667282-A | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2022-06-24 | — | — | CN | disclosed |
| WO-2021080980-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO., LTD. (TW) | 2021-04-29 | — | — | WO | disclosed |
| EP-0204529-B1 | ANTI-CANCER QUINAZOLINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 1993-03-31 | — | — | EP | disclosed |
| US-5187167-A | Antitumor agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-16 | — | — | US | disclosed |
| US-5081124-A | Amino acid and polyamino acid derivatives, inhibitors of thymidylate synthetase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-01-14 | — | — | US | disclosed |
| EP-0239362-B1 | ANTI-TUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-04 | — | — | EP | disclosed |
| US-4767758-A | RADIOSENSITIZING CELLS; BLOCKING REACTION OF OXYGEN RADICALS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1988-08-30 | — | — | US | disclosed |
| EP-0204529-A2 | Anti-cancer quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 1986-12-10 | — | — | EP | disclosed |
| EP-0186252-A2 | Use of thiophene compounds for the manufacture of a medicament against tumours | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1986-07-02 | — | — | EP | disclosed |
| US-4061851-A | 7-Amino-7-arylthio cephalosporins | E. R. SQUIBB & SONS, INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-4026886-A | 7-Acyl-7-arylthiocephalosporins | E. R. SQUIBB & SONS, INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-3954744-A | ANTIBACTERIAL | E. R. SQUIBB & SONS, INC. (US) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125356-A1 | TREATMENT OF LEISHMANIASIS | NR1H2, NR1H3, MSR1 | SMN1; SMN2 1833/4885LMNA 1064/4885HTT 4861/4885 |
| US-20240150356-A1 | Pyrimidine amide compounds and use thereof | TYMP, DPYD, TYMS | SMN1; SMN2 1301/4885LMNA 3275/4885HTT 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.