Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30270357 | 0.82 | ATM (0.50) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL218867 | 0.82 | SMN1; SMN2 (0.53) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL6736049 | 0.80 | SMN1; SMN2 (0.51) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL1937600 | 0.80 | LMNA (0.54) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| Hydrochloric Acid SCHEMBL7036575 | 0.80 | SMN1; SMN2 (0.51) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL23529356 | 0.80 | SMN1; SMN2 (0.53) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL27938343 | 0.79 | SMN1; SMN2 (0.54) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL6261682 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTRAB9AMAPT | |
| SCHEMBL22493028 | 0.78 | SMN1; SMN2 (0.57) | ATMSMN1; SMN2LMNAHTTRAB9A | |
| SCHEMBL23561312 | 0.76 | LMNA (0.48) | ATMSMN1; SMN2LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114667282-B | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2024-09-03 | — | — | CN | claimed |
| US-9949970-B2 | Synthesis of new benzothiazole derivatives as potential anti-tubercular agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | claimed |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-06-23 | — | — | US | claimed |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2012-04-19 | — | — | US | claimed |
| EP-0186252-B1 | USE OF THIOPHENE COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT AGAINST TUMOURS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1992-04-01 | — | — | EP | claimed |
| CN-114667282-B | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114667282-A | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2022-06-24 | — | — | CN | disclosed |
| US-10071995-B2 | Substituted oxopyridine derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| EP-3197889-B1 | SUBSTITUTED OXOPYRIDINE DERIVATIVES | Bayer Pharma AG (DE) | 2018-08-01 | — | — | EP | disclosed |
| EP-3197889-B1 | SUBSTITUTED OXOPYRIDINE DERIVATIVES | Bayer Pharma AG (DE) | 2018-08-01 | — | — | EP | disclosed |
| US-20180127401-A1 | SUBSTITUTED OXOPYRIDINE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-10 | — | — | US | disclosed |
| US-20180127401-A1 | SUBSTITUTED OXOPYRIDINE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-10 | — | — | US | disclosed |
| CN-1440412-A | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301517-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| WO-2002002567-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| EP-0186252-B1 | USE OF THIOPHENE COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT AGAINST TUMOURS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1992-04-01 | — | — | EP | disclosed |
| US-4767758-A | RADIOSENSITIZING CELLS; BLOCKING REACTION OF OXYGEN RADICALS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1988-08-30 | — | — | US | disclosed |
| EP-0186252-A2 | Use of thiophene compounds for the manufacture of a medicament against tumours | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1986-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127401-A1 | SUBSTITUTED OXOPYRIDINE DERIVATIVES | OGFOD1, PNPO, VASP | ATM 1448/4885SMN1; SMN2 3201/4885LMNA 2253/4885 |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, TBCA, SDHA | ATM 1657/4885SMN1; SMN2 4865/4885LMNA 3273/4885 |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, SDHB, SDHA | ATM 635/4885SMN1; SMN2 3952/4885LMNA 3375/4885 |
| US-10071995-B2 | Substituted oxopyridine derivatives | OGFOD1, PNPO, VASP | ATM 1448/4885SMN1; SMN2 3201/4885LMNA 2253/4885 |
| US-20020028841-A1 | Thienopyrrolidinones | TNF, TYMP, TNFRSF1A | ATM 2257/4885SMN1; SMN2 342/4885LMNA 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.