SCHEMBL6737705

SCHEMBL6737705

O=C(Oc1ncc(-c2ccncc2)cn1)N1CCN(S(=O)(=O)N2Cc3ccc(Cl)cc3C2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
F10 P00742 1/20 0.37
FNTA P49354 5/20 0.36
FNTB P49356 5/20 0.36
MAPT P10636 2/20 0.35
AKR1C3 P42330 2/20 0.35
AKR1C1 Q04828 1/20 0.35
LMNA P02545 1/20 0.35
GLA P06280 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CHRM1 P11229 1/20 0.35
HSD17B10 Q99714 1/20 0.34
LSS P48449 2/20 0.33
CPT2 P23786 1/20 0.33
CPT1A P50416 1/20 0.33
GPR142 Q7Z601 1/20 0.33
TRPA1 O75762 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6726423 0.89 MAPT (0.37) ALDH1A1F10FNTAFNTBMAPT
SCHEMBL6725627 0.85 CYP11B2 (0.36) ALDH1A1F10FNTAFNTBMAPT
SCHEMBL6729950 0.81 AKR1C3 (0.44) FNTAFNTBMAPTAKR1C3AKR1C1
SCHEMBL6730433 0.80 LSS (0.54) ALDH1A1F10AKR1C3LMNATSHR
SCHEMBL6726196 0.75 F10 (0.41) ALDH1A1F10MAPTSMN1; SMN2CHRM1
SCHEMBL6730820 0.75 ALDH1A1 (0.38) ALDH1A1F10MAPTLMNAGLA
SCHEMBL6735885 0.74 F10 (0.41) ALDH1A1F10MAPTLMNASMN1; SMN2
SCHEMBL6735703 0.74 LSS (0.47) ALDH1A1F10FNTAFNTBAKR1C3
SCHEMBL6725451 0.74 F10 (0.36) F10FNTAFNTBLMNA
SCHEMBL6732153 0.73 ALDH1A1 (0.37) ALDH1A1F10MAPTLMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 ALDH1A1 1316/4885F10 19/4885FNTA 2112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.