Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6739701 | 1.00 | MAPK1 (0.37) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL10116679 | 0.83 | ALDH1A1 (0.30) | ALDH1A1KDM4EMAPT | |
| SCHEMBL3576290 | 0.77 | NPSR1 (0.44) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL3576293 | 0.77 | NPSR1 (0.44) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL10175722 | 0.76 | MAPK1 (0.39) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL27714278 | 0.75 | HCAR2 (0.40) | TSHRALDH1A1KDM4EMAPTTET2 | |
| SCHEMBL15563291 | 0.75 | TSHR (0.37) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL15563292 | 0.75 | TSHR (0.37) | MAPK1RAB9AHSD17B10NPC1TSHR | |
| SCHEMBL15873736 | 0.74 | DGAT1 (0.39) | ALDH1A1KDM4EMAPTHCAR2 | |
| SCHEMBL12348409 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTTET2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497263-B2 | Pyrrolinone derivative and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2013-07-30 | — | — | US | disclosed |
| US-20120010199-A1 | NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KAI HIROYUKI (JP) | 2012-01-12 | — | — | US | disclosed |
| US-6713503-B1 | 1-(2,4-DIMETHYL-PHENYL)-2,4-DIHYDROXY-3-(4-METHYL-BENZOYL)-5-OXO-2,5 -DIHYDRO-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER | UNIVERSITY OF CENTRAL FLORIDA | 2004-03-30 | — | — | US | disclosed |
| US-6703426-B1 | 4-(4-CHLORO-PHENYL)-2,4-DIOXO-3- (PHENYL-HYDRAZONO)-BUTYRIC ACID ETHYL ESTER IS ADMINISTERED | UNIVERSITY OF CENTRAL FLORIDA | 2004-03-09 | — | — | US | disclosed |
| US-6686496-B1 | 4-OXO-2 BUTENOIC ACID AND 3-HYDRAZINO-2,4-DIOXOBUTANOIC ACID DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA | 2004-02-03 | — | — | US | disclosed |
| US-6638975-B1 | Treatment of breast cancer | UNIVERSITY OF CENTRAL FLORIDA | 2003-10-28 | — | — | US | disclosed |
| US-6602907-B1 | Treatment of breast cancer | UNIVERSITY OF CENTRAL FLORIDA | 2003-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010199-A1 | NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | P2RX3, P2RX2, P2RX1 | MAPK1 2964/4885RAB9A 1008/4885HSD17B10 4047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.