SCHEMBL6740837

SCHEMBL6740837

Cc1c(C(F)(F)F)cnc(OCc2ccccc2)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.42
MRGPRX4 Q96LA9 3/20 0.41
MAPK1 P28482 2/20 0.41
MAPT P10636 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
SLC6A4 P31645 2/20 0.39
ALDH1A1 P00352 3/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
PIN1 Q13526 1/20 0.39
HPGD P15428 2/20 0.38
LMNA P02545 2/20 0.38
HTT P42858 2/20 0.38
TSHR P16473 1/20 0.38
MCL1 Q07820 1/20 0.37
BAK1 Q16611 1/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6741566 0.84 L3MBTL1 (0.43) L3MBTL1MRGPRX4MAPK1MAPTTDP1
SCHEMBL6739678 0.80 MRGPRX4 (0.49) MRGPRX4ALDH1A1PIN1MCL1BAK1
SCHEMBL18338730 0.77 PIN1 (0.56) L3MBTL1MRGPRX4SLC6A4PIN1RXRA
SCHEMBL6741450 0.75 CYP2C9 (0.42) MRGPRX4MEN1KMT2ALMNAMCL1
SCHEMBL27656945 0.74 L3MBTL1 (0.44) L3MBTL1MRGPRX4MAPK1MAPTTDP1
SCHEMBL8431628 0.72 MRGPRX4 (0.52) L3MBTL1MRGPRX4MAPK1MAPTTDP1
SCHEMBL4284736 0.72 RXRA (0.40) L3MBTL1MRGPRX4MAPK1ALDH1A1HPGD
SCHEMBL29165912 0.72 L3MBTL1 (0.42) L3MBTL1MRGPRX4MAPK1MAPTTDP1
SCHEMBL24968170 0.71 MAOB (0.43) L3MBTL1MRGPRX4MAPK1SLC6A4ALDH1A1
SCHEMBL17240905 0.71 PIN1 (0.56) MRGPRX4MAPK1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040043903-A1 Herbicides; applying to plants BASF AKTIENGESELLSCHAFT (DE) 2004-03-04 US disclosed
EP-1335903-A1 2-ARYL-5-TRIFLUOROMETHYLPYRIDINES BASF AKTIENGESELLSCHAFT (DE) 2003-08-20 EP disclosed
WO-2002042275-A1 2-ARYL-5-TRIFLUOROMETHYLPYRIDINES BASF AKTIENGESELLSCHAFT (DE) 2002-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040043903-A1 Herbicides; applying to plants DDT, DRD1, DRD4 L3MBTL1 1135/4885MRGPRX4 1467/4885MAPK1 1708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.