SCHEMBL6741205

SCHEMBL6741205

Cc1ccc(Br)c(F)c1.[MgH2]

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 5/20 0.39
KCNH2 Q12809 2/20 0.39
KDM1B Q8NB78 2/20 0.39
NFE2L2 Q16236 4/20 0.39
ACHE P22303 3/20 0.38
ALDH1A1 P00352 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2A6 P11509 2/20 0.38
MAPK1 P28482 1/20 0.37
RCOR1 Q9UKL0 1/20 0.35
KIF11 P52732 1/20 0.34
NQO2 P16083 1/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
THRB P10828 1/20 0.33
ALOX15 P16050 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29570973 0.97
SCHEMBL157146 0.97
Fluoride SCHEMBL28080565 0.95 KDM1A (0.39) KDM1AKCNH2KDM1BNFE2L2ACHE
SCHEMBL2741575 0.79 KIF11 (0.46) KDM1AKCNH2KDM1BNFE2L2ACHE
SCHEMBL7559862 0.79 HTT (0.49) ALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL21863802 0.78 EGFR (0.43) KCNH2
SCHEMBL80216 0.77
SCHEMBL30316227 0.77
SCHEMBL2913077 0.76 ALDH1A1 (0.48) KDM1AKCNH2KDM1BNFE2L2ALDH1A1
Iodide SCHEMBL28053437 0.75 NFE2L2 (0.39) KDM1AKDM1BNFE2L2ACHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6683218-B1 REACTING AN ARYL FLUORIDE WITH HALOGENATED HYDROCARBON AND MAGNESIUM; METALLIZATION, BORATING; DISTILLING OUT DIETHYL ETHER OR TETRAHYDROFURAN SOLVENT NIPPON SHOKUBAI CO., LTD. (JP) 2004-01-27 US disclosed
EP-0825195-B1 PRODUCING PROCESS OF FLUOROARYL MAGNESIUM DERIVATIVE AND PRODUCING PROCESS OF (FLUOROARYL)BORANE COMPOUND NIPPON CATALYTIC CHEM IND (JP) 2003-11-12 EP disclosed
US-6057480-A Process for preparing fluoroaryl magnesium derivative and process for preparing (fluoroaryl) borane compound NIPPON SHOKUBAI CO., LTD. (JP) 2000-05-02 US disclosed
EP-0838466-A2 Producing process of (fluoroaryl) borane compound and producing process of tetrakis (fluoroaryl) borate derivative NIPPON SHOKUBAI CO., LTD. (JP) 1998-04-29 EP disclosed
EP-0825195-A1 PROCESS FOR THE PREPARATION OF FLUORINATED ARYLMAGNESIUM DERIVATIVES AND PROCESS FOR THE PREPARATION OF (FLUORINATED ARYL)BORON COMPOUNDS NIPPON SHOKUBAI CO., LTD. (JP) 1998-02-25 EP disclosed