Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30523532 | 0.89 | HTT (0.53) | HTTMAPK1LMNARAB9ASRD5A2 | |
| SCHEMBL286942 | 0.89 | HTT (0.53) | HTTMAPK1LMNARAB9ASRD5A2 | |
| SCHEMBL157146 | 0.81 | — | — | |
| SCHEMBL29570973 | 0.81 | — | — | |
| SCHEMBL590885 | 0.81 | ALDH1A1 (0.57) | HTTLMNARAB9AALDH1A1SMN1; SMN2 | |
| Fluoride SCHEMBL28080565 | 0.79 | KDM1A (0.39) | MAPK1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL6741205 | 0.79 | KDM1A (0.39) | MAPK1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL7694625 | 0.77 | RARB (0.44) | HTTMAPK1LMNARAB9AALDH1A1 | |
| SCHEMBL333891 | 0.76 | ALDH1A1 (0.47) | RAB9AALDH1A1HDAC1HDAC6NPC1 | |
| SCHEMBL29620496 | 0.76 | ALDH1A1 (0.47) | RAB9AALDH1A1HDAC1HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002079147-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002078702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-10-10 | — | — | WO | disclosed |