SCHEMBL6741302

SCHEMBL6741302

CCOC(=O)C(C)(C(=O)OCC)C(C)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.43
CYP4F2 P78329 3/20 0.38
CYP4A11 Q02928 3/20 0.38
PKM P14618 3/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.34
HSD17B10 Q99714 1/20 0.34
THRB P10828 1/20 0.34
ABCB11 O95342 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
HTR2A P28223 1/20 0.34
PMP22 Q01453 1/20 0.34
PPARA Q07869 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4414269 0.79 MMP8 (0.48) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL1245711 0.77 MMP8 (0.38) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL28527763 0.77 MMP8 (0.38) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL25254884 0.76 MEN1 (0.43) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL11228383 0.75 MMP8 (0.46) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL16781658 0.75 ALDH1A1 (0.39) MMP8ALDH1A1KDM4ELMNAHSD17B10
SCHEMBL6741832 0.75 ALDH1A1 (0.39) MMP8PKMALDH1A1KDM4EMEN1
SCHEMBL12552335 0.75 MMP8 (0.46) MMP8CYP4F2CYP4A11PKMALDH1A1
SCHEMBL1784836 0.75 ALDH1A1 (0.39) MMP8ALDH1A1LMNAHSD17B10CYP3A4
SCHEMBL28462746 0.74 MMP8 (0.36) MMP8CYP4F2CYP4A11PKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11186660-B2 Internal electron donor compound for preparing α-olefin polymerization catalyst component YINGKOU XIANGYANG CATALYST CO., LTD. 2021-11-30 US claimed
US-20190218317-A1 INTERNAL ELECTRON DONOR COMPOUND FOR PREPARING ALPHA-OLEFIN POLYMERIZATION CATALYST COMPONENT YINGKOU XIANGYANG CATALYST CO LTD (CN) 2019-07-18 US claimed
US-10287371-B2 Internal electron donor compound for preparing α-olefin polymerization catalyst component YINGKOU XIANGYANG CATALYST CO., LTD. (CN) 2019-05-14 US claimed
US-20160229935-A1 Internal Electron Donor Compound for Preparing Alpha-olefin Polymerization Catalyst Component DALIAN UNIVERSITY OF TECHNOLOGY (CN) 2016-08-11 US claimed
EP-1042372-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SPA (IT) 2004-07-14 EP claimed
CN-1146585-C catalyst component and catalyst for olefin polymerization ض� 2004-04-21 CN claimed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US claimed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US claimed
CN-1292800-A catalyst component and catalyst for olefin polymerization MONTELL TECHNOLOGY COMPANY BV (NL) 2001-04-25 CN claimed
US-11186660-B2 Internal electron donor compound for preparing α-olefin polymerization catalyst component YINGKOU XIANGYANG CATALYST CO., LTD. 2021-11-30 US disclosed
US-10954324-B2 Catalyst component for high activity and high stereoselectivity in olefin polymerization FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2021-03-23 US disclosed
US-20190218317-A1 INTERNAL ELECTRON DONOR COMPOUND FOR PREPARING ALPHA-OLEFIN POLYMERIZATION CATALYST COMPONENT YINGKOU XIANGYANG CATALYST CO LTD (CN) 2019-07-18 US disclosed
US-10287371-B2 Internal electron donor compound for preparing α-olefin polymerization catalyst component YINGKOU XIANGYANG CATALYST CO., LTD. (CN) 2019-05-14 US disclosed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US disclosed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US disclosed
CN-1292800-A catalyst component and catalyst for olefin polymerization MONTELL TECHNOLOGY COMPANY BV (NL) 2001-04-25 CN disclosed