Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5997701 | 0.87 | METAP1 (0.39) | METAP1CCR6MITFHSP90AA1 | |
| Hydrochloric Acid SCHEMBL29441540 | 0.85 | METAP1 (0.41) | METAP1CCR6MITFHSP90AA1 | |
| SCHEMBL12721211 | 0.81 | METAP1 (0.38) | METAP1CCR6MITFHSP90AA1 | |
| SCHEMBL3965498 | 0.78 | METAP1 (0.41) | METAP1CCR6MITFHSP90AA1 | |
| SCHEMBL10710085 | 0.77 | CA1 (0.38) | CA1CA2CA4KMT2A | |
| SCHEMBL6906976 | 0.75 | CA1 (0.37) | CA1CA2CA4KMT2A | |
| SCHEMBL23747126 | 0.74 | LMNA (0.40) | KMT2A | |
| SCHEMBL18588301 | 0.72 | — | — | |
| SCHEMBL6903125 | 0.72 | — | — | |
| SCHEMBL83778 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322593-B1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-07-28 | — | — | EP | claimed |
| CN-1478067-A | O-substituted 6-methyl-tramadol derivatives | — | 2004-02-25 | — | — | CN | claimed |
| EP-1322593-A1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | Grünenthal GmbH (DE) | 2003-07-02 | — | — | EP | claimed |
| WO-2002026694-A1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-04 | — | — | WO | claimed |
| US-6828345-B2 | Tertiary amines such as 2-dimethylaminomethyl-1-(3-methoxy-phenyl)-6-methylcyclohexanol, used as analgesics | GRUENENTHAL GMBH (DE) | 2004-12-07 | — | — | US | disclosed |
| EP-1322593-B1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-07-28 | — | — | EP | disclosed |
| CN-1478067-A | O-substituted 6-methyl-tramadol derivatives | — | 2004-02-25 | — | — | CN | disclosed |
| US-20030220389-A1 | O-substituted 6-methyltramadol derivatives | GRUENENTHAL GMBH (DE) | 2003-11-27 | — | — | US | disclosed |
| EP-1322593-A1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | Grünenthal GmbH (DE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026694-A1 | O-SUBSTITUTED 6-METHYL-TRAMADOL DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220389-A1 | O-substituted 6-methyltramadol derivatives | OPRK1, TPMT, OPRM1 | METAP1 920/4885CA1 4499/4885CA2 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.