Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CD44 | P16070 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL27579793 | 0.75 | RAPGEF4 (0.41) | ALDH1A1TSHRTDP1TP53MAPT | |
| SCHEMBL112391 | 0.73 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| SCHEMBL41001 | 0.73 | RAPGEF4 (0.45) | ALDH1A1TSHRTDP1TP53MAPT | |
| SCHEMBL33589 | 0.73 | ALDH1A1 (0.65) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| SCHEMBL260795 | 0.73 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| SCHEMBL28040386 | 0.71 | RAPGEF4 (0.43) | ALDH1A1TSHRTDP1TP53MAPT | |
| Hydrochloric Acid SCHEMBL23198661 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| Hydrochloric Acid SCHEMBL970560 | 0.71 | ALDH1A1 (0.61) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7931830 | 0.71 | ALDH1A1 (0.61) | ALDH1A1TSHRPDE10ACASP1CYP3A4 | |
| SCHEMBL3246567 | 0.71 | ALDH1A1 (0.43) | ALDH1A1TSHRPDE10ACASP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689771-B2 | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-6376665-B1 | ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-23 | — | — | US | disclosed |