SCHEMBL6741780

SCHEMBL6741780

O=C1C=C(c2ccccc2)C(=O)N1C(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.46
ALDH1A1 P00352 3/20 0.46
MAPT P10636 3/20 0.46
NPSR1 Q6W5P4 3/20 0.46
GAA P10253 2/20 0.46
CCR6 P51684 2/20 0.46
ALOX12 P18054 2/20 0.46
CACNA1B Q00975 2/20 0.46
APBA1 Q02410 2/20 0.46
P2RX4 Q99571 3/20 0.42
BACE1 P56817 1/20 0.41
BCHE P06276 2/20 0.41
ACHE P22303 2/20 0.41
LMNA P02545 2/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL151352 0.84 MAPT (0.50) HPGDALDH1A1MAPTNPSR1GAA
SCHEMBL14541192 0.81 RGS4 (0.45) HPGDALDH1A1P2RX4BCHEACHE
SCHEMBL9240802 0.81 MAPT (0.47) HPGDALDH1A1MAPTNPSR1GAA
SCHEMBL787690 0.77 P2RX4 (0.43) HPGDNPSR1P2RX4BCHEACHE
SCHEMBL787853 0.77 MAPT (0.44) HPGDALDH1A1MAPTNPSR1GAA
SCHEMBL11257093 0.72 MAPK13 (0.42) ALDH1A1MAPTNPSR1P2RX4BCHE
SCHEMBL152219 0.72 MAPT (0.53) HPGDALDH1A1MAPTNPSR1GAA
SCHEMBL9836525 0.71 P2RX4 (0.44) HPGDALDH1A1NPSR1P2RX4BCHE
SCHEMBL1321593 0.71 P2RX4 (0.57) HPGDALDH1A1NPSR1CCR6P2RX4
SCHEMBL9323705 0.70 ALDH1A1 (0.38) HPGDALDH1A1MAPTNPSR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785107-B2 Lithographic printing plate precursor EASTMAN KODAK COMPANY (US) 2014-07-22 US disclosed
US-20130196268-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR BANK OF AMERICA, N.A., AS AGENT 2013-08-01 US disclosed
EP-2620813-A1 LITHOGRAPHIC PRINTING PLATE ORIGINAL Eastman Kodak Company (US) 2013-07-31 EP disclosed
US-6689539-B2 A FLUORORESIN HAVING A FLUORO ALIPHATIC GROUP OF 3 TO 20 CARBON ATOMS IN WHICH ATLEAST TWO OF THREE TERMINAL HYDROGEN ATOMS ARE SUBSTITUTED FOR FLUORINE ATOMS, AND AN ETHYLENE BASED UNSATURATED GROUP; AND A NEGATIVE PHOTOSENSITIVE KODAK POLYCHROME GRAPHICS LLC 2004-02-10 US disclosed
US-20020048721-A1 Photosensitive composition and photosensitive lithographic printing plate KODAK POLYCHROME GRAPHICS L.L.C. 2002-04-25 US disclosed