Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 8/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6742483 | 1.00 | KDM4E (0.55) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL3386727 | 0.81 | ADRA2C (0.57) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL7892362 | 0.81 | ADRA2C (0.57) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| Water SCHEMBL10366292 | 0.79 | ADRA2C (0.55) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| Hydrochloric Acid SCHEMBL3386662 | 0.79 | ADRA2C (0.55) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| Bromide SCHEMBL306447 | 0.79 | ADRA2C (0.55) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL3569539 | 0.76 | CYP2D6 (0.47) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL7900506 | 0.76 | CYP2D6 (0.47) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL26858831 | 0.76 | CYP2D6 (0.47) | KDM4EADRA2CLMNAADRA2AHIF1A | |
| SCHEMBL26858844 | 0.74 | ADRA2C (0.50) | KDM4EADRA2CLMNAADRA2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106654-A1 | Inhibitors of copper-containing amine oxidases | SMITH DAVID JOHN (FI) | 2004-06-03 | — | — | US | claimed |
| US-20020173521-A1 | Inhibitors of copper-containing amine oxidases | BIOTIE THERAPIES CORP. | 2002-11-21 | — | — | US | claimed |
| US-20040106654-A1 | Inhibitors of copper-containing amine oxidases | SMITH DAVID JOHN (FI) | 2004-06-03 | — | — | US | disclosed |
| US-6624202-B2 | Antiinflammatory agents; antiarthritic agents; skin disorders | BIOTIE THERAPIES CORP. (FI) | 2003-09-23 | — | — | US | disclosed |
| US-20020173521-A1 | Inhibitors of copper-containing amine oxidases | BIOTIE THERAPIES CORP. | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106654-A1 | Inhibitors of copper-containing amine oxidases | VCAM1, AOC3, AOC2 | KDM4E 1735/4885ADRA2C 1443/4885LMNA 4636/4885 |
| US-20020173521-A1 | Inhibitors of copper-containing amine oxidases | VCAM1, AOC3, AOC2 | KDM4E 1735/4885ADRA2C 1443/4885LMNA 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.