SCHEMBL6742796

SCHEMBL6742796

[CH2]Oc1c(C#N)cccc1[N+](=O)[O-]

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 1/20 0.42
TDP1 Q9NUW8 3/20 0.41
GRIA1 P42261 2/20 0.41
GRIA2 P42262 2/20 0.41
GRIA3 P42263 2/20 0.41
GRIA4 P48058 2/20 0.41
GRM6 O15303 1/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 2/20 0.40
MEN1 O00255 1/20 0.40
F2 P00734 1/20 0.40
KMT2A Q03164 1/20 0.40
GPR35 Q9HC97 1/20 0.40
PIN1 Q13526 1/20 0.39
NPC1 O15118 1/20 0.39
RECQL P46063 1/20 0.39
RAB9A P51151 1/20 0.39
HSPB1 P04792 1/20 0.38
KDM4D Q6B0I6 1/20 0.38
MAPT P10636 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6742801 0.83 TDP1 (0.47) VCAM1TDP1GRIA1GRIA2GRIA3
Water SCHEMBL28314114 0.80 MEN1 (0.43) VCAM1TDP1GRIA1GRIA2GRIA3
SCHEMBL9829866 0.80 LMNA (0.50) VCAM1TDP1GRIA1GRIA2GRIA3
SCHEMBL30204899 0.80 LMNA (0.50) VCAM1TDP1GRIA1GRIA2GRIA3
SCHEMBL6736892 0.78 TSHR (0.41) ALDH1A1MAPTCYP1A2LMNATSHR
SCHEMBL6742110 0.77 VCAM1 (0.46) VCAM1TDP1GRIA1GRIA2GRIA3
Tert-Butanol SCHEMBL29273186 0.77 ALDH1A1 (0.41) VCAM1TDP1ALDH1A1MEN1F2
SCHEMBL56638 0.76 VCAM1 (0.56) VCAM1TDP1GRIA1GRIA2GRIA3
SCHEMBL29382907 0.76 VCAM1 (0.56) VCAM1TDP1GRIA1GRIA2GRIA3
SCHEMBL220318 0.75 VCAM1 (0.47) VCAM1TDP1GRIA1GRIA2GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6689771-B2 TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-02-10 US disclosed
US-6610731-B2 Antiinflammatory BRISTOL-MYERS SQUIBB COMPANY 2003-08-26 US disclosed
US-6403632-B1 CYCLIC AMIDE DERIVATIVE BRISTOL MYERS SQUIBB PHARMA CO (US) 2002-06-11 US disclosed
US-6376665-B1 ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-23 US disclosed
EP-1165500-A1 AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE Du Pont Pharmaceuticals Company (US) 2002-01-02 EP disclosed
WO-2000059874-A1 NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE DU PONT PHARMACEUTICALS COMPANY (US) 2000-10-12 WO disclosed
US-6057336-A ANTIINFLAMMATORY AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-05-02 US disclosed