Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746652 | 0.90 | CA1 (0.40) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6744788 | 0.88 | PTGS2 (0.48) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6744241 | 0.88 | FEN1 (0.43) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6746864 | 0.86 | FEN1 (0.42) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6743148 | 0.86 | PTGS2 (0.51) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6747196 | 0.86 | CA1 (0.43) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6745954 | 0.86 | PTGS2 (0.42) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6722065 | 0.86 | PTGS2 (0.43) | FEN1PTGS2PTGS1RPS6KA3CA1 | |
| SCHEMBL6747351 | 0.85 | FEN1 (0.41) | FEN1PTGS2PTGS1CA1CA2 | |
| SCHEMBL6746016 | 0.85 | RORB (0.43) | FEN1PTGS2PTGS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |