Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260948 | 0.81 | NPC1 (0.53) | LMNACYP1A2CYP3A4MAOAHTT | |
| Hydrochloric Acid SCHEMBL6744451 | 0.80 | EP300 (0.41) | ROCK1 | |
| SCHEMBL12199135 | 0.78 | CA1 (0.68) | LMNACYP1A2CYP3A4MAOAHTT | |
| SCHEMBL8083373 | 0.78 | SUCNR1 (0.45) | LMNACYP1A2NAMPTCA12CA1 | |
| SCHEMBL7491665 | 0.77 | NOS1 (0.54) | LMNACYP1A2CYP3A4MAOAHTT | |
| SCHEMBL12228832 | 0.73 | CYP1A2 (0.59) | LMNACYP1A2CYP3A4MAOACDC7 | |
| SCHEMBL10765170 | 0.73 | CYP4A11 (0.62) | LMNACYP1A2CYP3A4MAOAHTT | |
| SCHEMBL5734417 | 0.73 | LMNA (0.68) | LMNACYP1A2CYP3A4MAOAHTT | |
| SCHEMBL571227 | 0.72 | CA1 (0.63) | LMNACYP1A2CYP3A4MAOAHTT | |
| SCHEMBL16664040 | 0.71 | CA12 (0.58) | LMNACYP1A2CYP3A4MAOAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693101-B2 | ALKANOIC ACID DERIVATIVE; INTEGRIN RECEPTOR ANTAGONIST | MERCK & CO., INC. | 2004-02-17 | — | — | US | disclosed |
| US-20010053853-A1 | Alpha V integrin receptor antagonists | MERCK & CO., INC. | 2001-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053853-A1 | Alpha V integrin receptor antagonists | ITGAV, ADGRE5, ITGA5 | LMNA 3379/4885CYP1A2 4151/4885CYP3A4 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.