Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGAV | P06756 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743269 | 0.81 | LMNA (0.50) | NPC1RAB9ACYP1A2LMNACYP3A4 | |
| SCHEMBL12199135 | 0.80 | CA1 (0.68) | NPC1RAB9AALDH1A1MAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL5248414 | 0.79 | ITGB3 (0.52) | ALDH1A1ITGB3ITGAVITGA2BBACE1 | |
| SCHEMBL7491665 | 0.78 | NOS1 (0.54) | NPC1RAB9AALDH1A1MAPTPKM | |
| SCHEMBL8083373 | 0.76 | SUCNR1 (0.45) | NPC1RAB9AALDH1A1MAPTCYP1A2 | |
| SCHEMBL4227353 | 0.76 | RAB9A (0.47) | NPC1RAB9AALDH1A1MAPTPKM | |
| SCHEMBL17921392 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1MAPTNPSR1CYP1A2LMNA | |
| Hydrochloric Acid SCHEMBL8356277 | 0.74 | NPC1 (0.51) | NPC1RAB9AALDH1A1PKMTDP1 | |
| SCHEMBL5734417 | 0.74 | LMNA (0.68) | ALDH1A1MAPTNPSR1TDP1CYP1A2 | |
| SCHEMBL5117605 | 0.74 | CA12 (0.59) | NPC1RAB9AALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252162-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-07-25 | — | — | EP | disclosed |
| EP-1252162-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-07-25 | — | — | EP | disclosed |
| EP-1187592-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1315501-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1315501-B1 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-7153862-B2 | αv integrin receptor antagonists | MERCK & CO., INC. (US) | 2006-12-26 | — | — | US | disclosed |
| US-7109191-B2 | Benzazepinone alpha vintegrin receptor antagonists | MERCK & CO., INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-7056909-B2 | Alpha v integrin receptor antagonists | MERCK & CO., INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1331937-B1 | DIBENZOXAZEPINE ALPHA V INTEGRIN RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 2006-03-15 | — | — | EP | disclosed |
| US-6943156-B2 | Dibenzoxazepine αv integrin receptor antagonist | MERCK & CO., INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-6090944-A | Alkanoic acid derivatives as αv integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | disclosed |
| US-6048861-A | OSTEOPOROSIS; BONE DISORDERS; CARDIOVASCULAR DISORDERS; ANTIINFLAMMATROY AGENTS; WOUND HEALING AGENTS | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |
| US-6040311-A | TREATING BONE DISORDERS FOR PREVENTING OSTEOPOROSIS OR INHIBITING BONE RESORPTION IN A MAMMAL; TREATING TUMOR GROWTH IN A MAMMAL | MERCK & CO., INC. (US) | 2000-03-21 | — | — | US | disclosed |
| WO-2000006169-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |
| US-6017926-A | Integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |
| US-6017925-A | Integrin antagonists | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |
| US-5981546-A | Integrin antagonists | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5952341-A | VITRONECTIN RECEPTOR ANTAGONISTS FOR INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING RESTENOSIS, DIABETIC RETINOPATHY, TUMOR, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5919792-A | Integrin antagonists | MERCK & CO., INC. (US) | 1999-07-06 | — | — | US | disclosed |