Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28143256 | 0.83 | CTNNB1 (0.42) | PARP10KMT2ACTNNB1TDP1L3MBTL1 | |
| SCHEMBL29102453 | 0.81 | PARP10 (0.38) | PARP10MEN1KMT2ACTNNB1TDP1 | |
| SCHEMBL23327088 | 0.79 | ELANE (0.41) | TDP1L3MBTL1TSHRHSD17B10CYP3A4 | |
| SCHEMBL28790608 | 0.79 | AOC2 (0.39) | PARP10CTNNB1TDP1L3MBTL1ALOX15 | |
| SCHEMBL28591821 | 0.76 | KMT2A (0.41) | KMT2AL3MBTL1TSHRHSD17B10MAPT | |
| SCHEMBL27700260 | 0.75 | ELANE (0.45) | KMT2ATDP1L3MBTL1TSHRCYP2C19 | |
| SCHEMBL8885 | 0.74 | LTA4H (0.50) | TDP1L3MBTL1TSHRRECQLALOX15 | |
| SCHEMBL29102439 | 0.72 | PARP10 (0.37) | PARP10MEN1KMT2ACTNNB1TDP1 | |
| Hydrochloric Acid SCHEMBL693111 | 0.71 | LTA4H (0.47) | MEN1KMT2ATDP1L3MBTL1TSHR | |
| Carbamic Acid Phenyl Ester SCHEMBL7566 | 0.70 | MEN1 (0.70) | PARP10MEN1KMT2ACTNNB1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606052-B1 | NICOTINIC RECEPTOR COMPOUNDS | RES TRIANGLE INST (US) | 2016-06-01 | — | — | EP | disclosed |
| US-9284322-B2 | Nicotinic receptor compounds | RESEARCH TRIANGLE INSTITUTE (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150307502-A9 | NICOTINIC RECEPTOR COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-29 | — | — | US | disclosed |
| US-9150581-B2 | Nicotinic receptor compounds | RESEARCH TRIANGLE INSTITUTE (US) | 2015-10-06 | — | — | US | disclosed |
| US-20150152119-A1 | NICOTINIC RECEPTOR COMPOUNDS | RES TRIANGLE INST (US) | 2015-06-04 | — | — | US | disclosed |
| US-8981102-B2 | Nicotinic receptor compounds | RESEARCH TRIANGLE INSTITUTE (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140357674-A1 | NICOTINIC RECEPTOR COMPOUNDS | RES TRIANGLE INST (US) | 2014-12-04 | — | — | US | disclosed |
| WO-2013101802-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2013-07-04 | — | — | WO | disclosed |
| EP-2606052-A1 | NICOTINIC RECEPTOR COMPOUNDS | Research Triangle Institute (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130150373-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2013-06-13 | — | — | US | disclosed |
| WO-2012024615-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-02-23 | — | — | WO | disclosed |
| CN-101675051-A | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors | WYETH CORP | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150373-A1 | NICOTINIC RECEPTOR COMPOUNDS | CHRNG, CHRNA7, CHRNA2 | PARP10 2475/4885MEN1 3946/4885KMT2A 3824/4885 |
| US-20150307502-A9 | NICOTINIC RECEPTOR COMPOUNDS | CHRNB4, CHRNA4, CHRNB2 | PARP10 4395/4885MEN1 4521/4885KMT2A 1465/4885 |
| US-20140357674-A1 | NICOTINIC RECEPTOR COMPOUNDS | CHRNB4, CHRNA4, CHRNB2 | PARP10 4395/4885MEN1 4521/4885KMT2A 1465/4885 |
| US-20150152119-A1 | NICOTINIC RECEPTOR COMPOUNDS | CHRNG, CHRNA7, CHRNA2 | PARP10 2475/4885MEN1 3946/4885KMT2A 3824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.