Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 10/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KYAT1 | Q16773 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744865 | 1.00 | GAA (0.53) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL6751587 | 0.83 | ALDH1A1 (0.56) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL6744870 | 0.83 | ALDH1A1 (0.56) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL6746778 | 0.81 | LMNA (0.52) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL6746773 | 0.81 | LMNA (0.52) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL21176924 | 0.79 | CES2 (0.55) | GAALMNAALDH1A1HPGDTP53 | |
| SCHEMBL4081557 | 0.78 | GAA (0.52) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4081554 | 0.78 | GAA (0.52) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL5318594 | 0.76 | CES2 (0.59) | GAALMNAALDH1A1HPGDATM | |
| SCHEMBL23348046 | 0.76 | GAA (0.58) | GAALMNANPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703426-B1 | 4-(4-CHLORO-PHENYL)-2,4-DIOXO-3- (PHENYL-HYDRAZONO)-BUTYRIC ACID ETHYL ESTER IS ADMINISTERED | UNIVERSITY OF CENTRAL FLORIDA | 2004-03-09 | — | — | US | disclosed |