Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351602 | 0.75 | HTT (0.47) | KDM4EALDH1A1HSD17B10CYP1A2POLB | |
| SCHEMBL15048563 | 0.72 | KDM4E (0.43) | PDE10AKDM4ENPC1RAB9AMAPT | |
| SCHEMBL694051 | 0.70 | ALDH1A1 (0.42) | PDE10AKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL12203630 | 0.69 | KDM4E (0.62) | PDE10AKDM4ENPC1RAB9AMAPT | |
| SCHEMBL745547 | 0.68 | KDM4E (0.53) | PDE10AKDM4ENPC1RAB9AMAPT | |
| SCHEMBL10550468 | 0.67 | KDM4E (0.71) | PDE10AKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL21474653 | 0.67 | KDM4E (0.53) | PDE10AKDM4ENPC1RAB9AMAPT | |
| Dipyridyl SCHEMBL28760321 | 0.66 | KDM4E (0.88) | PDE10AKDM4ENPC1RAB9AMAPT | |
| Dipyridyl SCHEMBL27651116 | 0.66 | KDM4E (0.88) | KDM4ENPC1RAB9AMAPTATM | |
| Dipyridyl SCHEMBL3711450 | 0.66 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268368-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Alios Biopharma, Inc. (US) | 2018-01-17 | — | — | EP | claimed |
| WO-2016145103-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2016-09-15 | — | — | WO | claimed |
| US-20040229863-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-11-18 | — | — | US | claimed |
| US-20030114437-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-06-19 | — | — | US | claimed |
| EP-1278502-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-05-21 | — | — | EP | claimed |
| EP-1278502-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001089451-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | claimed |
| EP-3268368-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Alios Biopharma, Inc. (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016145103-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144351-A1 | HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2016-09-15 | — | — | WO | disclosed |
| US-20040229863-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-11-18 | — | — | US | disclosed |
| US-20030114437-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114437-A1 | Protease inhibitors | CTSS, CTSE, CTSF | PDE10A 4404/4885KDM4E 2876/4885NPC1 690/4885 |
| US-20040229863-A1 | Protease inhibitors | CTSS, CTSE, CTSF | PDE10A 4404/4885KDM4E 2876/4885NPC1 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.