Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570741 | 0.81 | LMNA (0.43) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL13184169 | 0.79 | LMNA (0.55) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL4625127 | 0.78 | LMNA (0.54) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL9518977 | 0.78 | LMNA (0.54) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL16402642 | 0.75 | LMNA (0.51) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL17207364 | 0.74 | KMT2A (0.42) | LMNAKMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9268404 | 0.74 | HTT (0.36) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL5443096 | 0.74 | LMNA (1.00) | LMNAKMT2AL3MBTL1MAPTHTT | |
| SCHEMBL3331795 | 0.72 | CYP2C19 (0.41) | LMNAKMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16402575 | 0.72 | KMT2A (0.37) | LMNAKMT2AL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951169-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-28 | — | — | EP | disclosed |
| US-9926333-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-27 | — | — | US | disclosed |
| US-20170327514-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-9732093-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-15 | — | — | US | disclosed |
| US-20150368270-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-24 | — | — | US | disclosed |
| US-20150252008-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-10 | — | — | US | disclosed |
| US-20040019221-A1 | Processes for the preparation of pyrazole compounds | NIPPON SODA CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1318145-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE COMPOUNDS | NIPPON SODA CO., LTD. (JP) | 2003-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | LMNA 3996/4885KMT2A 3823/4885L3MBTL1 3612/4885 |
| US-20040019221-A1 | Processes for the preparation of pyrazole compounds | CBR1, CPS1, CYC1 | LMNA 1678/4885KMT2A 3491/4885L3MBTL1 4474/4885 |
| US-20150368270-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | LMNA 3996/4885KMT2A 3823/4885L3MBTL1 3612/4885 |
| US-20150252008-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | LMNA 4150/4885KMT2A 3757/4885L3MBTL1 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.