Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.50 |
| ▸ | UBE2M | P61081 | 1/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.45 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513400 | 0.83 | DRD2 (0.62) | OPRL1HTR1AOPRM1OPRK1DRD4 | |
| SCHEMBL3187063 | 0.81 | DRD2 (0.49) | OPRL1HTR1AOPRM1OPRK1DRD4 | |
| SCHEMBL3187067 | 0.81 | DRD2 (0.49) | OPRL1HTR1AOPRM1OPRK1DRD4 | |
| SCHEMBL1424423 | 0.79 | GRIN2B (0.52) | OPRL1OPRM1OPRK1DRD4DRD2 | |
| SCHEMBL1844431 | 0.79 | DRD2 (0.46) | OPRL1HTR1AOPRM1OPRK1DRD4 | |
| SCHEMBL1844428 | 0.79 | DRD2 (0.46) | OPRL1HTR1AOPRM1OPRK1DRD4 | |
| SCHEMBL1844989 | 0.79 | GRIN2B (0.52) | OPRL1OPRM1OPRK1DRD4DRD2 | |
| SCHEMBL1424424 | 0.79 | GRIN2B (0.52) | OPRL1OPRM1OPRK1DRD4DRD2 | |
| SCHEMBL1843594 | 0.78 | OPRK1 (0.61) | OPRM1OPRK1OPRD1 | |
| SCHEMBL1843593 | 0.78 | OPRK1 (0.61) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063728-A1 | 8-AZA-bicyclo[3.2.1]octan-3-OL derivative of 2,3-dihydro-1,4-benzodioxan as 5-HT 1A antagonists | WYETH | 2004-04-01 | — | — | US | disclosed |
| US-6656951-B2 | Treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease, or schizophrenia; also anxiety, aggression and stress; controlling appetite, thermoregulation, sleep and sexual behavior | WYETH | 2003-12-02 | — | — | US | disclosed |
| US-20030032648-A1 | 8-Aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benodioxan as 5-HT1A antagonists | WYETH | 2003-02-13 | — | — | US | disclosed |
| WO-2002085900-A1 | 8-AZA-BICYCLO[3.2.1]OCTAN-3-OL DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN AS 5-HT1A ANTAGONISTS | WYETH (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063728-A1 | 8-AZA-bicyclo[3.2.1]octan-3-OL derivative of 2,3-dihydro-1,4-benzodioxan as 5-HT 1A antagonists | HTR5A, HTR1A, HTR1D | OPRL1 110/4885CHRM4 474/4885HTR1A 2/4885 |
| US-20030032648-A1 | 8-Aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benodioxan as 5-HT1A antagonists | HTR5A, HTR1D, HTR1A | OPRL1 69/4885CHRM4 332/4885HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.