Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31469975 | 1.00 | OPRM1 (0.50) | OPRM1OPRK1OPRL1BRD4NOTUM | |
| SCHEMBL14075307 | 0.82 | BRD4 (0.44) | OPRM1OPRK1OPRL1BRD4BRPF1 | |
| SCHEMBL14075302 | 0.82 | NOTUM (0.42) | OPRM1OPRK1OPRL1BRD4NOTUM | |
| SCHEMBL28230741 | 0.80 | OPRM1 (0.49) | OPRM1OPRK1OPRL1BRD4NOTUM | |
| SCHEMBL19953762 | 0.80 | ALDH1A1 (0.46) | BRD4NOTUMBRPF1TSHRKMT2A | |
| SCHEMBL20335486 | 0.78 | ALDH1A1 (0.48) | OPRM1OPRK1OPRL1NOTUMTSHR | |
| SCHEMBL19953668 | 0.78 | HDAC4 (0.43) | BRD4NOTUMBRPF1TSHRKMT2A | |
| SCHEMBL30746803 | 0.77 | TSHR (0.65) | OPRM1BRD4BRPF1TSHRKMT2A | |
| SCHEMBL4989074 | 0.77 | TSHR (0.65) | OPRM1BRD4BRPF1TSHRKMT2A | |
| SCHEMBL6264071 | 0.77 | OPRM1 (0.44) | OPRM1OPRK1OPRL1BRD4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | ANDREANA TONJA LYNN (US) | 2004-07-15 | — | — | US | disclosed |
| EP-0409435-B1 | Heteroaryl piperazine antipsychotic agents | PFIZER (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5350747-A | Heteroaryl piperazine antipsychotic agents | PFIZER INC (US) | 1994-09-27 | — | — | US | disclosed |
| WO-1991000863-A1 | HETEROARYL PIPERAZINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0409435-A1 | Heteroaryl piperazine antipsychotic agents | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | CNR1, DRD2, CNR2 | OPRM1 15/4885OPRK1 19/4885OPRL1 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.