SCHEMBL19953668

SCHEMBL19953668

CN1C(=O)CC(C(N)=O)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
BRD4 O60885 1/20 0.41
TSHR P16473 2/20 0.40
ALDH1A1 P00352 2/20 0.40
NOTUM Q6P988 1/20 0.40
KMT2A Q03164 3/20 0.38
BRPF1 P55201 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MEN1 O00255 2/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
SLC6A2 P23975 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19953762 0.86 ALDH1A1 (0.46) HDAC4HDAC7HDAC5BRD4TSHR
SCHEMBL19960585 0.82 HDAC4 (0.48) HDAC4HDAC7HDAC5BRD4TSHR
SCHEMBL31469975 0.78 OPRM1 (0.50) HDAC4HDAC7HDAC5BRD4TSHR
SCHEMBL6746146 0.78 OPRM1 (0.50) HDAC4HDAC7HDAC5BRD4TSHR
SCHEMBL19953584 0.76 FABP5 (0.43) HDAC4HDAC7HDAC5KMT2ASMN1; SMN2
SCHEMBL19953533 0.76 FABP5 (0.43) HDAC4HDAC7HDAC5KMT2ASMN1; SMN2
SCHEMBL19953489 0.76 FABP5 (0.43) HDAC4HDAC7HDAC5KMT2ASMN1; SMN2
SCHEMBL19960839 0.75 HDAC4 (0.39) HDAC4HDAC7HDAC5BRD4KMT2A
SCHEMBL19953763 0.74 HDAC4 (0.42) HDAC4HDAC7HDAC5BRD4ALDH1A1
Hydrochloric Acid SCHEMBL19953504 0.74 HDAC4 (0.38) HDAC4HDAC7HDAC5BRD4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018047983-A1 INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-03-15 WO disclosed