Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.36 |
| ▸ | CTSC | P53634 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746666 | 0.91 | PTGS2 (0.36) | PTGS2ALOX5APFEN1PTGS1EPAS1 | |
| SCHEMBL6743648 | 0.86 | PTGS2 (0.40) | PTGS2ALOX5APFEN1PTGS1 | |
| SCHEMBL6746028 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL6746380 | 0.84 | PTGS2 (0.39) | PTGS2 | |
| SCHEMBL6746854 | 0.83 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL6747149 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1SCN9A | |
| SCHEMBL6750053 | 0.83 | PTGS2 (0.38) | PTGS2PTGS1 | |
| SCHEMBL6746412 | 0.81 | PTGS2 (0.34) | PTGS2CTSCPTGS1EPAS1CTSK | |
| SCHEMBL6745224 | 0.81 | NR1H2 (0.40) | PTGS2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6746140 | 0.81 | EPAS1 (0.37) | PIK3CAEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |