SCHEMBL6748657

SCHEMBL6748657

CCO[Si](OCC)(OCC)c1ccc(N(c2ccc(CC)cc2)c2ccc(-c3ccc(N(c4ccc(CC)cc4)c4ccc(CC)cc4)cc3)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.36
TP53 P04637 2/20 0.34
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
HSD17B10 Q99714 1/20 0.34
METAP2 P50579 1/20 0.33
HRH3 Q9Y5N1 3/20 0.32
LPL P06858 1/20 0.32
LIPG Q9Y5X9 1/20 0.32
UCHL1 P09936 1/20 0.32
EGFR P00533 1/20 0.32
NOTUM Q6P988 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31
ATM Q13315 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP17A1 P05093 1/20 0.31
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6748537 0.95 TP53 (0.36) NISCHTP53LMNAHTTHSD17B10
SCHEMBL14267361 0.91 TP53 (0.38) NISCHTP53LMNAMETAP2HRH3
SCHEMBL1306301 0.86
SCHEMBL3482503 0.86 TP53 (0.39) TP53LMNAMETAP2LPLLIPG
SCHEMBL6748524 0.85 NISCH (0.35) NISCHTP53LMNAHTTHSD17B10
SCHEMBL6852010 0.85 NISCH (0.35) NISCHTP53LMNAHTTHSD17B10
SCHEMBL6746672 0.85 ALDH1A1 (0.33) NOTUMSMN1; SMN2TSHRL3MBTL1NPC1
SCHEMBL12615158 0.85 ALDH1A1 (0.38) TP53SMN1; SMN2ATMTDP1L3MBTL1
SCHEMBL6745447 0.85 ALDH1A1 (0.38) TP53SMN1; SMN2ATMTDP1L3MBTL1
SCHEMBL6748564 0.85 NISCH (0.37) NISCHTP53LMNAHTTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 NISCH 187/4885TP53 3921/4885LMNA 3596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.