SCHEMBL6748783

SCHEMBL6748783

CC(C)(C)[Si](C)(C)OCc1ccsc1C=O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.38
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
DUT P33316 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1247148 0.85 DUT (0.34) DUT
SCHEMBL6746972 0.78 BACE1 (0.34) BACE1
SCHEMBL17410505 0.78 BACE1 (0.35) BACE1MAPTHPGDDUT
SCHEMBL5884329 0.76 BACE1 (0.34) BACE1MAPTHPGD
SCHEMBL6748908 0.76 BACE1 (0.35) BACE1
SCHEMBL9632119 0.75 SLC6A1 (0.33) MAPT
SCHEMBL12063377 0.72 CYP2A6 (0.30)
SCHEMBL30219107 0.72 BACE1 (0.56) BACE1HPGDDUT
SCHEMBL2082920 0.72 BACE1 (0.56) BACE1HPGDDUT
SCHEMBL3134778 0.72 BACE1 (0.32) BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6703373-B1 ANTICARCINOGENIC AGENTS BANYU PHARMACEUTICAL CO., LTD. (JP) 2004-03-09 US disclosed