Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.53 |
| ▸ | TOP1 | P11387 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748926 | 0.91 | ESR1 (0.49) | BCHEACHEALKTOP1HRH3 | |
| SCHEMBL6747002 | 0.88 | BCHE (0.43) | BCHEACHEALKTOP1HRH3 | |
| SCHEMBL7117346 | 0.86 | ALDH1A1 (0.53) | BCHEACHEMAPTKMT2A | |
| SCHEMBL6749914 | 0.81 | BCHE (0.58) | BCHEACHEHRH3MAPT | |
| SCHEMBL5924015 | 0.79 | MAPT (0.56) | BCHEACHEMAPTKMT2A | |
| SCHEMBL6749880 | 0.77 | BCHE (0.59) | BCHEACHEALKTOP1MCHR1 | |
| SCHEMBL8589084 | 0.77 | ESR1 (0.50) | BCHEACHEALKHRH3MAPT | |
| Hydrochloric Acid SCHEMBL6749922 | 0.76 | BCHE (0.58) | BCHEACHEALKTOP1MCHR1 | |
| Hydrochloric Acid SCHEMBL6746980 | 0.76 | ESR1 (0.51) | BCHEACHEALKHRH3XDH | |
| SCHEMBL4651950 | 0.75 | CNR2 (0.65) | BCHEACHEMCHR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703407-B1 | TREATMENT OF MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION | ELI LILLY AND COMPANY | 2004-03-09 | — | — | US | disclosed |
| EP-0774966-B1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-0774966-A4 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0774966-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996009040-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |