Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748926 | 0.90 | ESR1 (0.49) | BCHEACHEALKKDM4EALDH1A1 | |
| SCHEMBL6748797 | 0.88 | BCHE (0.58) | BCHEACHEALKKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL8589257 | 0.86 | BCHE (0.43) | BCHEACHEALKKDM4EALDH1A1 | |
| SCHEMBL7117346 | 0.85 | ALDH1A1 (0.53) | BCHEACHEKDM4EALDH1A1HPGD | |
| SCHEMBL6749914 | 0.80 | BCHE (0.58) | BCHEACHEKDM4EALDH1A1MAPT | |
| SCHEMBL5924015 | 0.78 | MAPT (0.56) | BCHEACHEKDM4EALDH1A1HPGD | |
| SCHEMBL6746958 | 0.77 | LTA4H (0.48) | BCHEACHEKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6748796 | 0.76 | LTA4H (0.47) | BCHEACHEKDM4EALDH1A1HPGD | |
| SCHEMBL8589084 | 0.76 | ESR1 (0.50) | BCHEACHEALKKDM4EALDH1A1 | |
| SCHEMBL4651843 | 0.76 | CNR2 (0.64) | BCHECYP3A4MAPTCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703407-B1 | TREATMENT OF MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION | ELI LILLY AND COMPANY | 2004-03-09 | — | — | US | disclosed |
| EP-0774966-B1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 2003-11-05 | — | — | EP | disclosed |