Sugi Predict

Sugi Predict / Compounds / SCHEMBL6749437

SCHEMBL6749437

SCHEMBL6749437

CCO[Si](C)(OCC)c1ccc(N(c2ccccc2)c2cccc(-c3cccc(N(c4ccccc4)c4ccccc4)c3)c2)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.33
▸ ALDH1A1 P00352 3/20 0.33
▸ MAPT P10636 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ FAAH O00519 1/20 0.33
▸ MGLL Q99685 1/20 0.33
▸ PTGDR2 Q9Y5Y4 1/20 0.32
▸ CHKA P35790 1/20 0.31
▸ TP53 P04637 3/20 0.31
▸ SMN1; SMN2 Q16637 3/20 0.31
▸ NPC1 O15118 2/20 0.31
▸ HPGD P15428 2/20 0.31
▸ RAB9A P51151 2/20 0.31
▸ TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6852490 0.92 ALDH1A1 (0.36) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6854722 0.92 ALDH1A1 (0.33) KDM4EALDH1A1MAPTCYP2D6CYP2C19
SCHEMBL6850671 0.89 ALDH1A1 (0.41) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6751440 0.88 KDM4E (0.33) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6855690 0.88 ALDH1A1 (0.37) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6858697 0.85 ALDH1A1 (0.35) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6853136 0.84 KMT2A (0.38) ALDH1A1MAPTCYP1A2CYP3A4CYP2C9
SCHEMBL6851969 0.84 ADRA2A (0.32) CYP2D6CYP2C19TP53TSHRLMNA
SCHEMBL6852172 0.83 CYP2C19 (0.39) KDM4EALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6848590 0.83 CYP2C19 (0.39) KDM4EALDH1A1MAPTCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 — — US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 — — EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 — — US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 — — US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 KDM4E 296/4885ALDH1A1 460/4885MAPT 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.