Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.53 |
| ▸ | LOX | P28300 | 1/20 | 0.53 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | MGMT | P16455 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.31 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755268 | 0.80 | GRM5 (0.41) | LOXL2LOXGRM5FFAR1NR3C2 | |
| SCHEMBL2927949 | 0.74 | LOXL2 (0.43) | LOXL2CYP11B1CYP11B2 | |
| SCHEMBL6751233 | 0.74 | LOXL2 (0.43) | LOXL2CYP11B1CYP11B2 | |
| SCHEMBL10159790 | 0.73 | RECQL (0.57) | LOXL2LOXLOXL3RECQLGRM5 | |
| SCHEMBL9280722 | 0.73 | RECQL (0.57) | LOXL2LOXLOXL3RECQLGRM5 | |
| SCHEMBL1437084 | 0.73 | LOXL2 (0.57) | LOXL2LOXLOXL3RECQLGRM5 | |
| SCHEMBL28455100 | 0.72 | PNMT (0.62) | PNMT | |
| SCHEMBL29556838 | 0.72 | HSD17B10 (0.55) | LOXL2LOXLOXL3RECQLEPHX1 | |
| SCHEMBL7270108 | 0.72 | HSD17B10 (0.55) | LOXL2LOXLOXL3RECQLEPHX1 | |
| SCHEMBL904475 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6759428-B2 | SUCH AS N-((1,2)-2-(((CYANO(CYCLOPROPYL)METHYL)AMINO)CARBONYL) CYCLOHEXYL)-1H-INDOLE-2-CARBOXAMIDE; CATHEPSIN K INHIBITORS | ROCHE PALO ALTO LLC | 2004-07-06 | — | — | US | disclosed |
| US-20040077646-A1 | Indole nitriles | ROCHE PALO ALTO LLC | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077646-A1 | Indole nitriles | TPH1, IDO1, NAT1 | LOXL2 2261/4885LOX 849/4885LOXL3 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.