Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.61 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454641 | 0.90 | PTGS2 (0.80) | PTGS2PTGS1 | |
| Tilmacoxib SCHEMBL379564 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Tilmacoxib SCHEMBL29382548 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7624378 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL3129581 | 0.84 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL6049793 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8376304 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8380758 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3128664 | 0.81 | PTGS2 (0.66) | PTGS2PTGS1PIK3CA | |
| SCHEMBL8376294 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020198244-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-12-26 | — | — | US | claimed |
| US-20020198245-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-12-26 | — | — | US | claimed |
| WO-2002078625-A2 | THERAPEUTIC COMBINATIONS FOR CARDIOVASCULAR AND INFLAMMATORY INDICATIONS | PHARMACIA CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| US-20020143040-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-10-03 | — | — | US | claimed |
| US-20020115701-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-08-22 | — | — | US | claimed |
| US-20020107270-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-08-08 | — | — | US | claimed |
| US-20020107271-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-08-08 | — | — | US | claimed |
| US-6362209-B1 | ANTIPYRETICS, ANALGESICS, ANTIINFLAMMATORY AGENTS | JAPAN TOBACCO INC. (JP) | 2002-03-26 | — | — | US | claimed |
| EP-0745596-B1 | HETEROAROMATIC OXAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO INC (JP) | 1999-05-19 | — | — | EP | claimed |
| EP-0745596-A1 | HETEROAROMATIC OXAZOLE COMPOUNDS AND USE THEREOF | Japan Tobacco Inc. (JP) | 1996-12-04 | — | — | EP | claimed |
| US-20080027011-A1 | Homogeneous paste and gel formulations | MERIAL LIMITED | 2008-01-31 | — | — | US | disclosed |
| US-20080027011-A1 | Homogeneous paste and gel formulations | MERIAL LIMITED | 2008-01-31 | — | — | US | disclosed |
| US-20040186154-A1 | Therapeutic combinations for cardiovascular and inflammatory indications | SEIBERT KAREN (US) | 2004-09-23 | — | — | US | disclosed |
| CN-1527709-A | Therapeutic combination for cardiovascular and inflammatory indications | — | 2004-09-08 | — | — | CN | disclosed |
| EP-1435956-A2 | THERAPEUTIC COMBINATIONS FOR CARDIOVASCULAR AND INFLAMMATORY INDICATIONS | Pharmacia Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20020107270-A1 | Heterocyclic aromatic oxazole compounds and use thereof | HARUTA JUNICHI (JP) | 2002-08-08 | — | — | US | disclosed |
| US-6362209-B1 | ANTIPYRETICS, ANALGESICS, ANTIINFLAMMATORY AGENTS | JAPAN TOBACCO INC. (JP) | 2002-03-26 | — | — | US | disclosed |
| US-5994381-A | ANTIPYRETICS; ANTIINFLAMMATORY AGENTS; ANALGESICS | JAPAN TOBACCO, INC. (JP) | 1999-11-30 | — | — | US | disclosed |
| EP-0745596-B1 | HETEROAROMATIC OXAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO INC (JP) | 1999-05-19 | — | — | EP | disclosed |
| EP-0745596-A1 | HETEROAROMATIC OXAZOLE COMPOUNDS AND USE THEREOF | Japan Tobacco Inc. (JP) | 1996-12-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198245-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 5/4885PTGS1 1/4885GPR119 661/4885 |
| US-20020115701-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 5/4885PTGS1 1/4885GPR119 661/4885 |
| US-20020143040-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 5/4885PTGS1 1/4885GPR119 661/4885 |
| US-20080027011-A1 | Homogeneous paste and gel formulations | EPX, CAT, PEF1 | PTGS2 329/4885PTGS1 101/4885GPR119 4214/4885 |
| US-20020198244-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 5/4885PTGS1 1/4885GPR119 661/4885 |
| US-20040186154-A1 | Therapeutic combinations for cardiovascular and inflammatory indications | HMGCR, HMGB2, HMGB3 | PTGS2 7/4885PTGS1 18/4885GPR119 1275/4885 |
| US-20020107270-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 6/4885PTGS1 1/4885GPR119 593/4885 |
| US-20020107271-A1 | Heterocyclic aromatic oxazole compounds and use thereof | PTGS1, OXER1, HRH2 | PTGS2 5/4885PTGS1 1/4885GPR119 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.