Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propanol SCHEMBL28701231 | 0.93 | — | — | |
| Propanol SCHEMBL3211695 | 0.90 | ALDH1A1 (0.39) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Chloroform SCHEMBL6508789 | 0.89 | — | — | |
| Propanol SCHEMBL1433302 | 0.89 | — | — | |
| Chloroform SCHEMBL2118727 | 0.86 | — | — | |
| Chloroform SCHEMBL4023266 | 0.86 | — | — | |
| Chloroform SCHEMBL1065585 | 0.86 | TSHR (0.55) | ALDH1A1TSHRLMNA | |
| Butyl Alcohol SCHEMBL3959051 | 0.85 | ALDH1A1 (0.61) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 | |
| Chloroform SCHEMBL2169183 | 0.82 | TSHR (0.50) | ALDH1A1TSHRLMNA | |
| Chloroform SCHEMBL28556246 | 0.82 | TSHR (0.50) | ALDH1A1TSHRSMN1; SMN2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058880-A1 | Aminoglycoside antibiotics as novel anti-infective agents | OPTIMER PHARMACEUTICALS, INC. | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058880-A1 | Aminoglycoside antibiotics as novel anti-infective agents | ALG8, GANAB, RPN2 | ALDH1A1 3703/4885TSHR 4531/4885SMN1; SMN2 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.